In this study, the anticonvulsant activity evaluation of a series of new 2,4(1H)-diarylimidazoles, characterized by the presence of different substituents on the aryl rings, was described. The anticonvulsant activity profile of those compounds was determined by Maximal Electroshock Seizure (MES), subcutaneous Metrazol Seizure (scMet) tests, and 6-Hz seizure model, whereas their neurotoxicity was examined using rotarod test. The trifluoromethoxy derivative, obtained starting from phenylglyoxal, p-OCF3-benzaldehyde, and ammonium acetate in methanol (r.t.), exhibited a great ability to prevent the seizures induced in the 6-Hz test, becoming a new promising molecule to develop for the treatment of therapyresistant partial seizures.