Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines

European Journal of Medicinal Chemistry
2010.0

Abstract

Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.

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