Solid-Supported Parallel Synthesis of Hydroxybenzylamine Libraries Possessing Antileishmial Activity

Medicinal Chemistry Research
2005.0

Abstract

A concise solid-supported parallel synthesis of 64 compounds is described. Starting with isovanillin, a two-step sequence involving reductive amination and Nbenzylation was performed to provide the compounds in good purity. The library has been tested against Leishmania donovani and Plasmodium falciparum, with activity at the micromolar level.

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