Pyrazole NNRTIs 3: Optimisation of physicochemical properties

Pyrazole NNRTIs 3: Optimisation of physicochemical properties Pyrazole NNRTIs 1: Design and initial optimisation of a novel template Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: Aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif Design of Annulated Pyrazoles as Inhibitors of HIV-1 Reverse Transcriptase Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase Pyrazole NNRTIs 4: Selection of UK-453,061 (lersivirine) as a Development Candidate Structural optimization of N1-aryl-benzimidazoles for the discovery of new non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains 1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole