Might Adrenergic α_2C-Agonists/α_2A-Antagonists Become Novel Therapeutic Tools for Pain Treatment with Morphine?

Might Adrenergic α_2C-Agonists/α_2A-Antagonists Become Novel Therapeutic Tools for Pain Treatment with Morphine? Fruitful Adrenergic α_2C-Agonism/α_2A-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence^, Favourable involvement of α2A-adrenoreceptor antagonism in the I2-imidazoline binding sites-mediated morphine analgesia enhancement α₂ Adrenoceptor Agonists as Potential Analgesic Agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene as a High-Affinity Ligand for the α_2D Adrenergic Receptor α₂-Adrenoreceptors Profile Modulation. 4. From Antagonist to Agonist Behavior Rigid Analogues of the α2-Adrenergic Blocker Atipamezole: Small Changes, Big Consequences Methylation of imidazoline related compounds leads to loss of α2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands .alpha.2-Adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines Combined Interactions with I₁-, I₂-Imidazoline Binding Sites and α₂-Adrenoceptors To Manage Opioid Addiction α₂ Adrenoceptor Agonists as Potential Analgesic Agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene as a High-Affinity Ligand for the α_2D Adrenergic Receptor