2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2 Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2 Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening