In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

Knowledge Graph

Similar Paper

In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones
Bioorganic & Medicinal Chemistry Letters 2010.0
Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum
Bioorganic & Medicinal Chemistry Letters 2017.0
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase
European Journal of Medicinal Chemistry 2018.0
Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation
European Journal of Medicinal Chemistry 2019.0
In Vitro and in Vivo Antileishmanial and Trypanocidal Studies of New N-Benzene- and N-Naphthalenesulfonamide Derivatives
Journal of Medicinal Chemistry 2013.0
Antiprotozoal Compounds from <i>Psorothamnus </i><i>p</i><i>olydenius</i>
Journal of Natural Products 2005.0
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds
Bioorganic &amp; Medicinal Chemistry Letters 2015.0
Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines
Bioorganic &amp; Medicinal Chemistry Letters 2006.0
Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure–activity relationship (SAR)
Bioorganic &amp; Medicinal Chemistry 2011.0
Antileishmanial Activity of Clinanthus milagroanthus S. Leiva &amp; Meerow (Amaryllidaceae) Collected in Peru
Plants 2023.0