Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

Spirodiketopiperazine-based CCR5 antagonists, showing improved pharmacokinetic profiles without reduction in antagonist activity, were designed and synthesized. We also demonstrate the anti-HIV activity of a representative compound 12, as measured in a p24 assay.

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