Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

In the screening for antitumor leads from microbial secondary metabolites, BU-4664L (1), a naturally occurring dibenzodiazepine, was found to inhibit tumor invasion and angiogenesis in vitro. Compound 1 inhibited the gelatinase activities of MMP-2 and MMP-9 and the cellular motility. Four derivatives (2-5) were synthesized from 1 and their antitumor activities were evaluated. Compounds 3 and 4 exhibited potent anti-angiogenic effects on HUVEC, together with remarkable inhibition of cell migration at nanomolar concentrations, and showed much lower cytotoxicity.

Knowledge Graph

Similar Paper

Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives
Bioorganic & Medicinal Chemistry Letters 2010.0
Synthesis and biological evaluation of BU-4664L derivatives as potential anticancer agents
Bioorganic & Medicinal Chemistry Letters 2022.0
Discovery of tetrandrine derivatives as tumor migration, invasion and angiogenesis inhibitors
Bioorganic Chemistry 2020.0
Discovery of novel 1,5-benzodiazepine-2,4-dione derivatives as potential anticancer agents
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis and evaluation of myxochelin analogues as antimetastatic agents
Bioorganic & Medicinal Chemistry 2009.0
Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis and tumor growth
European Journal of Medicinal Chemistry 2013.0
Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis
European Journal of Medicinal Chemistry 2012.0
Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors
European Journal of Medicinal Chemistry 2018.0
Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase
European Journal of Medicinal Chemistry 2019.0
Discovery of novel bis-evodiamine derivatives with potent antitumor activity
Bioorganic & Medicinal Chemistry 2022.0