Synthesis and evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazoles as antidepressant, anxiolytic, and anticonvulsant agents

Medicinal Chemistry Research
2009.0

Abstract

The purpose of this study was to evaluate the title compounds on central nervous system activity by varying the substituents in the thiadiazole moiety. The newly synthesized intermediates and compounds were characterized by spectral analysis. Two of the tested compounds (3a and 3b) exhibited excellent antidepressant, anxiolytic, and anticonvulsant activity in comparison with the reference drugs.

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