Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

European Journal of Medicinal Chemistry
2010.0

Abstract

The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.

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