Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-S-21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.

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