Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents Development of the First Two-Pore Domain Potassium Channel TWIK-Related K⁺Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists Analogues of Morphanthridine and the Tear Gas Dibenz[b,f][1,4]oxazepine (CR) as Extremely Potent Activators of the Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Sanguinarine is an agonist of TRPA1 channel Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic Discovery of natural TRPA1 activators through pharmacophore-based virtual screening and a biological assay