Bis-azaaromatic quaternary ammonium salts as ligands for the blood–brain barrier choline transporter

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained from this study suggest that incorporating a linear, conformationally restricted linker into the molecule improves affinity for the BBB-ChT.

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