Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A new series of antimicrobial derivatives [3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole)] have been synthesized with potent activity against strains of Staphylococcus aureus, including methicillin-resistant strains (MRSA). Compound 17 [3-(4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl)-5-bromo-1H-indole], the most active derivative was shown to inhibit the growth of all Gram-positive strains tested, including vancomycin resistant Enterococcus faecalis and Enterococcus faecium with no activity against Gram-negative bacteria.

Knowledge Graph

Similar Paper

Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus
Bioorganic & Medicinal Chemistry Letters 2010.0
Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA
European Journal of Medicinal Chemistry 2009.0
Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents
Bioorganic & Medicinal Chemistry 2011.0
Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives – An extended structure–activity relationship study
European Journal of Medicinal Chemistry 2008.0
Novel boronic acid derivatives of bis(indolyl) methane as anti-MRSA agents
Bioorganic & Medicinal Chemistry Letters 2017.0
Design, synthesis and biological evaluation of novel indole-piperazine derivatives as antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2023.0
Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives
European Journal of Medicinal Chemistry 2011.0
Synthesis and in vitro activity of dicationic indolyl diphenyl ethers as novel potent antibiotic agents against drug-resistant bacteria
Bioorganic & Medicinal Chemistry Letters 2017.0
Design, synthesis and structure–activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity
Bioorganic & Medicinal Chemistry Letters 2004.0
Indole-based derivatives as potential antibacterial activity against methicillin-resistance Staphylococcus aureus (MRSA)
European Journal of Medicinal Chemistry 2020.0