Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives

European Journal of Medicinal Chemistry
2010.0

Abstract

Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.

Knowledge Graph

Similar Paper

Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives
European Journal of Medicinal Chemistry 2010.0
Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents
European Journal of Medicinal Chemistry 2014.0
Synthesis of indazole based diarylurea derivatives and their antiproliferative activity against tumor cell lines
Bioorganic & Medicinal Chemistry Letters 2013.0
Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors
Bioorganic & Medicinal Chemistry 2012.0
Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazinylcarbonyl moiety
Medicinal Chemistry Research 2013.0
Design, synthesis, and biological evaluation of novel quinazolinyl-diaryl urea derivatives as potential anticancer agents
European Journal of Medicinal Chemistry 2016.0
Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents
Bioorganic & Medicinal Chemistry 2012.0
New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: Design, synthesis, and antiproliferative activity against melanoma cell line
Bioorganic & Medicinal Chemistry Letters 2012.0
Discovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents
European Journal of Medicinal Chemistry 2016.0
Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents
European Journal of Medicinal Chemistry 2014.0