In Vitro Potency of CXA-101, a Novel Cephalosporin, against Pseudomonas aeruginosa Displaying Various Resistance Phenotypes, Including Multidrug Resistance

Antimicrobial Agents and Chemotherapy
2010.0

Abstract

We describe the activity of a novel cephalosporin, CXA-101 (FR26 4205), against a panel of highly resistant Pseudomonas aeruginosa isolates collected from U.S. hospitals. CXA-101 demonstrated increased potency against this population of resistant isolates, with activity that is 4- to 10-fold higher than that of comparator agents in each phenotypic category. The addition of tazobactam did not improve its activity. CXA-101 appears to be a promising addition to the category of antipseudomonal beta-lactams.

DOI： 10.1128/aac.00912-09

Knowledge Graph

Similar Paper

In Vitro Potency of CXA-101, a Novel Cephalosporin, against Pseudomonas aeruginosa Displaying Various Resistance Phenotypes, Including Multidrug Resistance
Antimicrobial Agents and Chemotherapy 2010.0
Activity of a New Antipseudomonal Cephalosporin, CXA-101 (FR264205), against Carbapenem-Resistant and Multidrug-Resistant Pseudomonas aeruginosa Clinical Strains
Antimicrobial Agents and Chemotherapy 2010.0
Activity of a New Cephalosporin, CXA-101 (FR264205), against β-Lactam-Resistant Pseudomonas aeruginosa Mutants Selected In Vitro and after Antipseudomonal Treatment of Intensive Care Unit Patients
Antimicrobial Agents and Chemotherapy 2010.0
Affinity of the New Cephalosporin CXA-101 to Penicillin-Binding Proteins ofPseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy 2010.0
In Vitro and In Vivo Activities of a New Cephalosporin, FR264205, against Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy 2007.0
In Vitro Potentiation of Carbapenems with ME1071, a Novel Metallo-β-Lactamase Inhibitor, against Metallo-β-Lactamase- Producing Pseudomonas aeruginosa Clinical Isolates
Antimicrobial Agents and Chemotherapy 2010.0
Synthesis and in vitro antibacterial activity of new aminothiazole-oximepiperidone cephalosporins
Bioorganic & Medicinal Chemistry Letters 2021.0
Detection of the Novel Extended-Spectrum β-Lactamase OXA-161 from a Plasmid-Located Integron inPseudomonas aeruginosaClinical Isolates from Spain
Antimicrobial Agents and Chemotherapy 2009.0
Extended-Spectrum Cephalosporinases in Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy 2009.0
In Vitro Profiling of Ceftaroline against a Collection of Recent Bacterial Clinical Isolates from across the United States
Antimicrobial Agents and Chemotherapy 2008.0