Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

Bioorganic & Medicinal Chemistry
2010.0

Abstract

Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain.

Knowledge Graph

Similar Paper

Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity
Bioorganic & Medicinal Chemistry 2010.0
Design, Synthesis, and Preliminary Pharmacological Evaluation of 4-Aminopiperidine Derivatives as N-Type Calcium Channel Blockers Active on Pain and Neuropathic Pain
Journal of Medicinal Chemistry 2004.0
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers
Bioorganic & Medicinal Chemistry Letters 2011.0
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model
Bioorganic & Medicinal Chemistry Letters 2019.0
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives
Bioorganic & Medicinal Chemistry 2017.0
Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment
European Journal of Medicinal Chemistry 2016.0
Synthesis and evaluation of 6-pyrazoylamido-3 N -substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain
Bioorganic & Medicinal Chemistry 2016.0
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers
Bioorganic & Medicinal Chemistry Letters 2012.0
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers
Bioorganic & Medicinal Chemistry Letters 2013.0