Purmorphamine activates the Hedgehog pathway by targeting Smoothened

Purmorphamine activates the Hedgehog pathway by targeting Smoothened Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway Acylthiourea, Acylurea, and Acylguanidine Derivatives with Potent Hedgehog Inhibiting Activity Modulators of the hedgehog signaling pathway Current trends in Hedgehog signaling pathway inhibition by small molecules A small molecule that binds Hedgehog and blocks its signaling in human cells Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells