Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A series of novel quercetin diacylglucosides were designed and first synthesized by Steglich esterification on the basis of MRSA strains inhibiting natural compound A. The in vitro inhibition of different multi-drug resistant bacterial strains and Escherichia coli DNA gyrase B was investigated. In the series, compound 10h was up to 128-fold more potent against vancomycin-resistant enterococci and more effective than A, which represents a promising new candidate as a potent anti-MRSA and anti-VRE agent.

Knowledge Graph

Similar Paper

Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents
Bioorganic & Medicinal Chemistry Letters 2010.0
Quercetin Diacylglycoside Analogues Showing Dual Inhibition of DNA Gyrase and Topoisomerase IV as Novel Antibacterial Agents
Journal of Medicinal Chemistry 2011.0
Synthesis and structure–activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and in vitro activity of dicationic indolyl diphenyl ethers as novel potent antibiotic agents against drug-resistant bacteria
Bioorganic & Medicinal Chemistry Letters 2017.0
Synthesis and biological evaluation of novel N, N′-diarylurea derivatives as potent antibacterial agents against MRSA
Bioorganic & Medicinal Chemistry Letters 2022.0
Synthesis of quercetin glycosides and their melanogenesis stimulatory activity in B16 melanoma cells
Bioorganic & Medicinal Chemistry 2014.0
Efficient bioconversion of quercetin into a novel glycoside by Streptomyces rimosus subsp. rimosus ATCC 10970
Journal of Bioscience and Bioengineering 2013.0
Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase
Bioorganic & Medicinal Chemistry Letters 2009.0
Design, synthesis and structure–activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents
Bioorganic & Medicinal Chemistry Letters 2013.0