Combined ramR Mutation and Presence of a Tn 1721 -Associated tet (A) Variant in a Clinical Isolate of Salmonella enterica Serovar Hadar Resistant to Tigecycline

Antimicrobial Agents and Chemotherapy
2010.0

Abstract

A Salmonella enterica serovar Hadar strain resistant to tigecycline (MIC, 16 microg/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wild-type ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate implicates ramR in resistance to tigecycline.

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