Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition Structure–Activity Relationships Among the Nitrogen Containing Bisphosphonates in Clinical Use and Other Analogues: Time-Dependent Inhibition of Human Farnesyl Pyrophosphate Synthase Pyridinium-1-yl Bisphosphonates Are Potent Inhibitors of Farnesyl Diphosphate Synthase and Bone Resorption Bisphosphonates target multiple sites in both cis - and trans -prenyltransferases Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis Farnesyl Diphosphate Synthase Inhibitors With Unique Ligand-Binding Geometries Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase