Effect of 14-Membered-Ring Macrolides on Production of Interleukin-8 Mediated by Protease-Activated Receptor 2 in Human Keratinocytes

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes. Those macrolides may attenuate the protease-activated receptor 2-interleukin-8 axis and thereby modulate proinflammatory responses in the skin.

Knowledge Graph

Similar Paper

Effect of 14-Membered-Ring Macrolides on Production of Interleukin-8 Mediated by Protease-Activated Receptor 2 in Human Keratinocytes
Antimicrobial Agents and Chemotherapy 2008.0
Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes
Antimicrobial Agents and Chemotherapy 2009.0
Roxithromycin Favorably Modifies the Initial Phase of Resistance against Infection with Macrolide-Resistant Streptococcus pneumoniae in a Murine Pneumonia Model
Antimicrobial Agents and Chemotherapy 2007.0
4″-O-(ω-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens
Bioorganic & Medicinal Chemistry 2010.0
N′-Substituted-2′-O,3′-N-carbonimidoyl Bridged Macrolides: Novel Anti-inflammatory Macrolides without Antimicrobial Activity
Journal of Medicinal Chemistry 2012.0
Efficacy of Clarithromycin against Experimentally Induced Pneumonia Caused by Clarithromycin-Resistant Haemophilus influenzae in Mice
Antimicrobial Agents and Chemotherapy 2010.0
Induction of erm (C) Expression by Noninducing Antibiotics
Antimicrobial Agents and Chemotherapy 2008.0
Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity
Bioorganic & Medicinal Chemistry Letters 2009.0
Enhancement of Biofilm Formation by Subinhibitory Concentrations of Macrolides in icaADBC- Positive and -Negative Clinical Isolates of Staphylococcus epidermidis
Antimicrobial Agents and Chemotherapy 2010.0
A comparative NMR study between the macrolide antibiotic roxithromycin and erythromycin A with different biological properties
Journal of Medicinal Chemistry 1991.0