Induction of L1 and L2 β-Lactamase Production inStenotrophomonas maltophiliaIs Dependent on an AmpR-Type Regulator

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

A divergently oriented ampR has been located upstream of blaL2 in Stenotrophomonas maltophilia. AmpR is necessary for L1 and L2 beta-lactamase induction in response to beta-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.

DOI： 10.1128/aac.01485-07

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