In Vitro Phenotypic Susceptibility of Human Immunodeficiency Virus Type 2 Clinical Isolates to Protease Inhibitors

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

We determine phenotypic susceptibility of human immunodeficiency virus type 2 (HIV-2) isolates to amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, saquinavir, and tipranavir. Saquinavir, lopinavir, and darunavir are potent against wild-type HIV-2 isolates and should be preferred as first-line options for HIV-2-infected patients. Other protease inhibitors are less active against HIV-2 than against HIV-1.

Knowledge Graph

Similar Paper

In Vitro Phenotypic Susceptibility of Human Immunodeficiency Virus Type 2 Clinical Isolates to Protease Inhibitors
Antimicrobial Agents and Chemotherapy 2008.0
In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 2 with Decreased Susceptibility to Lopinavir
Antimicrobial Agents and Chemotherapy 2007.0
Natural Polymorphisms in the Human Immunodeficiency Virus Type 2 Protease Can Accelerate Time to Development of Resistance to Protease Inhibitors
Antimicrobial Agents and Chemotherapy 2007.0
Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains
Bioorganic & Medicinal Chemistry Letters 2004.0
Characterization of a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, A-790742
Antimicrobial Agents and Chemotherapy 2008.0
Antimalarial Asexual Stage-Specific and Gametocytocidal Activities of HIV Protease Inhibitors
Antimicrobial Agents and Chemotherapy 2010.0
Human Immunodeficiency Virus Types 1 and 2 Exhibit Comparable Sensitivities to Zidovudine and Other Nucleoside Analog Inhibitors In Vitro
Antimicrobial Agents and Chemotherapy 2008.0
Prevalence, Mutation Patterns, and Effects on Protease Inhibitor Susceptibility of the L76V Mutation in HIV-1 Protease
Antimicrobial Agents and Chemotherapy 2010.0
Betulinic Acid Derivatives as Human Immunodeficiency Virus Type 2 (HIV-2) Inhibitors
Journal of Medicinal Chemistry 2009.0
Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Journal of Medicinal Chemistry 1998.0