Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

Knowledge Graph

Similar Paper

Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis
Antimicrobial Agents and Chemotherapy 2008.0
Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis
Antimicrobial Agents and Chemotherapy 2008.0
Efficacy of Triazoles in a Murine Disseminated Infection by Candida krusei
Antimicrobial Agents and Chemotherapy 2009.0
Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species
Journal of Medicinal Chemistry 2022.0
Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole
Antimicrobial Agents and Chemotherapy 2010.0
Cispentacin, a new antifungal antibiotic. II. In vitro and in vivo antifungal activities.
The Journal of Antibiotics 1989.0
Interactions between Triazoles and Amphotericin B in Treatment of Disseminated Murine Infection by Fusarium oxysporum
Antimicrobial Agents and Chemotherapy 2009.0
Activity of Anidulafungin in a Murine Model of Candida krusei Infection: Evaluation of Mortality and Disease Burden by Quantitative Tissue Cultures and Measurement of Serum (1,3)-β- <scp>d</scp> -Glucan Levels
Antimicrobial Agents and Chemotherapy 2009.0
Efficacy of Single-Dose Liposomal Amphotericin B or Micafungin Prophylaxis in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis
Antimicrobial Agents and Chemotherapy 2008.0
In Vitro Activity of the New Azole Isavuconazole (BAL4815) Compared with Six Other Antifungal Agents against 162 Cryptococcus neoformans Isolates from Cuba
Antimicrobial Agents and Chemotherapy 2008.0