Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A series of novel coumarin bisindole heterocycles were synthesized following an uncommon method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 12 compounds tested, the compound 5e showed potent antihyperlipidemic activity and was found to decrease the plasma triglyceride levels (TG) by 55%, total cholesterol (TC) by 20%, accompanied by an increase in HDL-C/TC ratio by 42% in hyperlipidemic rats to a greater degree than some of the reference statins.

Knowledge Graph

Similar Paper

Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives
Bioorganic & Medicinal Chemistry Letters 2010.0
Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents
Bioorganic & Medicinal Chemistry Letters 2011.0
Hybrids of coumarin–indole: design, synthesis and biological evaluation in Triton WR-1339 and high-fat diet induced hyperlipidemic rat models
MedChemComm 2016.0
Hypolipidemic activity of phthalimide derivatives. 7. Structure-activity studies of indazolone analogs
Journal of Medicinal Chemistry 1984.0
Hypolipidemic activity of phthalimide derivatives. 2. N-Phenylphthalimide and derivatives
Journal of Medicinal Chemistry 1983.0
Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity
Bioorganic & Medicinal Chemistry Letters 2009.0
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia
European Journal of Medicinal Chemistry 2021.0
Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity
Bioorganic & Medicinal Chemistry Letters 2011.0
Heterocyclic analogs of chlorcyclizine with potent hypolipidemic activity
Journal of Medicinal Chemistry 1984.0
Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents
European Journal of Medicinal Chemistry 2011.0