Kinetic Characterization of VIM-7, a Divergent Member of the VIM Metallo-β-Lactamase Family

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.

Knowledge Graph

Similar Paper

Kinetic Characterization of VIM-7, a Divergent Member of the VIM Metallo-β-Lactamase Family
Antimicrobial Agents and Chemotherapy 2008.0
Biochemical Characterization of Metallo-β-Lactamase VIM-11 from a Pseudomonas aeruginosa Clinical Strain
Antimicrobial Agents and Chemotherapy 2008.0
VIM-19, a Metallo-β-Lactamase with Increased Carbapenemase Activity from Escherichia coli and Klebsiella pneumoniae
Antimicrobial Agents and Chemotherapy 2010.0
VIM-15 and VIM-16, Two New VIM-2-Like Metallo-β-Lactamases in Pseudomonas aeruginosa Isolates from Bulgaria and Germany
Antimicrobial Agents and Chemotherapy 2008.0
Novel VIM Metallo-β-Lactamase Variant from Clinical Isolates of Enterobacteriaceae from Algeria
Antimicrobial Agents and Chemotherapy 2010.0
Mutational Analysis of VIM-2 Reveals an Essential Determinant for Metallo-β-Lactamase Stability and Folding
Antimicrobial Agents and Chemotherapy 2010.0
Characterization of the New Metallo-β-Lactamase VIM-13 and Its Integron-Borne Gene from a Pseudomonas aeruginosa Clinical Isolate in Spain
Antimicrobial Agents and Chemotherapy 2008.0
E240V Substitution Increases Catalytic Efficiency toward Ceftazidime in a New Natural TEM-Type Extended-Spectrum β-Lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens Clinical Isolates
Antimicrobial Agents and Chemotherapy 2008.0
New Variant of CTX-M-Type Extended-Spectrum β-Lactamases, CTX-M-71, with a Gly238Cys Substitution in a K lebsiella pneumoniae Isolate from Bulgaria
Antimicrobial Agents and Chemotherapy 2009.0
Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-β-Lactamase Clones (VIM-2, -5, -6, and -11 and the Newly Characterized VIM-18)
Antimicrobial Agents and Chemotherapy 2009.0