Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase fromKlebsiella pneumoniae

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

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