Artemisinin–quinoline hybrid-dimers: Synthesis and in vitro antiplasmodial activity

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

Novel artemisinin-quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90-110°C). All compounds were obtained as the β-isomers and were tested against both chloroquine sensitive and resistant strains of Plasmodium falciparum. Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms.

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