New chemotherapeutic drugs are the need to improve tuberculosis (TB) control particularly due to the emergence of multidrug-resistant strains and extensively drug-resistant strains of TB. These antitubercular compounds have different chemical moieties in their structure. Quinolones are generally used against many Gram-positive and Gram-negative bacteria. They are also active against atypical mycobacteria. Some quinolones (ciprofloxacin, levofloxacin, etc.) inhibit strains of Mycobacterium tuberculosis at concentrations <2.0 lg/mL. Fluoroquinolones are an important recent addition to the drugs available for TB, especially for strains that are resistant to first-line agents. The present review provides an overview of the drugs that are being used have quinolone moieties in TB treatment.