Codetection of bla OXA-23 -Like Gene ( bla OXA-133 ) and bla OXA-58 in Acinetobacter radioresistens : Report from the SENTRY Antimicrobial Surveillance Program

Antimicrobial Agents and Chemotherapy
2009.0

Abstract

We read with great interest the report from Poirel et al. (7) describing Acinetobacter radioresistens as a source of blaOXA-23 like genes. During the 2006 SENTRY Antimicrobial Surveillance Program, the occurrence of acquired class D carbapenemases and metallo---lactamases in Acinetobacter spp. from the Asia-Pacific region was evaluated (4). In this study, one A. radioresistens strain (251-39C; identified by 16S rRNA gene sequencing) showing decreased susceptibility to penicillins and imipenem was observed (Manipal, India). However, since blaOXA-23-like genes from all A. radioresistens strains described by Poirel et al. (7) were silent and chromosome borne and did not confer a resistance phenotype, we were intrigued by the elevated MICs displayed by the isolate 251-39C. Therefore, further screening for class D carbapenemase (6, 10) detected blaOXA-58 in addition to the intrinsic blaOXA-23-like gene.

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