Literature

Abstract

We report herein the synthesis and biological activity of a new kind of azetidinone derivatives of benzotriazole. The reaction was carried out by both conventional and microwave methods. The chemical structures of all the synthesized compounds were deduced according to FTIR, (1)H NMR, (13)C NMR and FAB-mass spectral along with microanalytical data. All the synthesized compounds of series 5a-i were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37RV and antimicrobial activity against some selected microorganism. Unexpectedly, some azetidinone derivatives of benzotriazole displayed better activities.

DOI： 10.1016/j.bmcl.2010.10.057

Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: A new class of biological compounds

Bioorganic & Medicinal Chemistry Letters 2011.0

Microwave-assisted synthesis of N-alkylated benzotriazole derivatives: Antimicrobial studies

Bioorganic & Medicinal Chemistry Letters 2006.0

Microwave-assisted synthesis of pyrido[1,2-a]benzimidazole derivatives of β-aryloxyquinoline and their antimicrobial and antituberculosis activities

Medicinal Chemistry Research 2013.0

Conventional and microwave assisted synthesis of Some new N-[(4-oxo-2-substituted aryl −1, 3-thiazolidine)-acetamidyl]-5-nitroindazoles and its antimicrobial activity

European Journal of Medicinal Chemistry 2010.0

Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives

Bioorganic & Medicinal Chemistry Letters 2012.0

Synthesis and bioactivity of novel triazole incorporated benzothiazinone derivatives as antitubercular and antioxidant agent