Comparative Efficacies of Telavancin and Vancomycin in Preventing Device-Associated Colonization and Infection by Staphylococcus aureus in Rabbits

Antimicrobial Agents and Chemotherapy
2009.0

Abstract

Telavancin is an investigational lipoglycopeptide antibiotic that is active against gram-positive pathogens. In an in vivo rabbit model, subtherapeutic (15-mg/kg) and therapeutic (30- or 45-mg/kg) doses of telavancin were demonstrated to be noninferior and superior to vancomycin (20 mg/kg), respectively, for preventing subcutaneous implant colonization and infection by Staphylococcus aureus.

Knowledge Graph

Similar Paper

Comparative Efficacies of Telavancin and Vancomycin in Preventing Device-Associated Colonization and Infection by Staphylococcus aureus in Rabbits
Antimicrobial Agents and Chemotherapy 2009.0
Efficacy of Telavancin in the Treatment of Experimental Endocarditis Due to Glycopeptide-Intermediate Staphylococcus aureus
Antimicrobial Agents and Chemotherapy 2007.0
Comparative Surveillance Study of Telavancin Activity against Recently Collected Gram-Positive Clinical Isolates from across the United States
Antimicrobial Agents and Chemotherapy 2008.0
In Vitro Activities of Telavancin and Vancomycin against Biofilm-Producing Staphylococcus aureus , S . epidermidis , and Enterococcus faecalis Strains
Antimicrobial Agents and Chemotherapy 2009.0
Activity of Telavancin against Staphylococcus aureus Strains with Various Vancomycin Susceptibilities in an In Vitro Pharmacokinetic/Pharmacodynamic Model with Simulated Endocardial Vegetations
Antimicrobial Agents and Chemotherapy 2009.0
In Vitro Activity of Telavancin against a Contemporary Worldwide Collection of Staphylococcus aureus Isolates
Antimicrobial Agents and Chemotherapy 2010.0
Comparative Efficacies of Human Simulated Exposures of Telavancin and Vancomycin against Methicillin-Resistant Staphylococcus aureus with a Range of Vancomycin MICs in a Murine Pneumonia Model
Antimicrobial Agents and Chemotherapy 2010.0
In Vitro Evaluation of the Activities of Telavancin, Cefazolin, and Vancomycin against Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Peritoneal Dialysate
Antimicrobial Agents and Chemotherapy 2007.0
In Vitro Activity of Telavancin against Resistant Gram-Positive Bacteria
Antimicrobial Agents and Chemotherapy 2008.0
In Vitro Activities of Telavancin and Six Comparator Agents against Anaerobic Bacterial Isolates
Antimicrobial Agents and Chemotherapy 2009.0