In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to IS Aba1 -Mediated Overexpression of the Natural bla OXA-66 Oxacillinase Gene

Antimicrobial Agents and Chemotherapy
2009.0

Abstract

Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of the naturally occurring bla(OXA-66) carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the bla(OXA-66) gene.

DOI： 10.1128/aac.01663-08

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