Evaluation of Target Specificity of Antibacterial Agents Using Staphylococcus aureus ddlA Mutants and d -Cycloserine in a Silkworm Infection Model

Antimicrobial Agents and Chemotherapy
2009.0

Abstract

The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness of antibiotics was examined. The 50% effective doses (ED50) of D-cycloserine against the Staphylococcus aureus ddlA mutant-mediated killing of larvae were remarkably lower than those against the parental strain-mediated killing of larvae. Changes in MICs and ED50 of other antibiotics were negligible, suggesting that these alterations are d-cycloserine selective. Therefore, this model is useful for selecting desired compounds based on their therapeutic effectiveness during antibiotic development.

Knowledge Graph

Similar Paper

Evaluation of Target Specificity of Antibacterial Agents Using Staphylococcus aureus ddlA Mutants and <scp>d</scp> -Cycloserine in a Silkworm Infection Model
Antimicrobial Agents and Chemotherapy 2009.0
Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties
The Journal of Antibiotics 2010.0
Bombyxamycins A and B, Cytotoxic Macrocyclic Lactams from an Intestinal Bacterium of the Silkworm <i>Bombyx mori</i>
Organic Letters 2019.0
Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. II: Structure elucidation
The Journal of Antibiotics 2010.0
<scp>dd</scp>-Diketopiperazines:  Antibiotics Active against Vibrio anguillarum Isolated from Marine Bacteria Associated with Cultures of Pecten maximus
Journal of Natural Products 2003.0
Isolation of L-cycloserine from Erwinia uredovora.
The Journal of Antibiotics 1984.0
Galleria mellonella as a Model System To Study Acinetobacter baumannii Pathogenesis and Therapeutics
Antimicrobial Agents and Chemotherapy 2009.0
Metabolomics Reveal <scp>d</scp>-Alanine:<scp>d</scp>-Alanine Ligase As the Target of <scp>d</scp>-Cycloserine in Mycobacterium tuberculosis
ACS Medicinal Chemistry Letters 2013.0
<scp>dd</scp>-Diketopiperazines:  Antibiotics Active against <i>Vibrio </i><i>a</i><i>nguillarum</i> Isolated from Marine Bacteria Associated with Cultures of<i> Pecten </i><i>m</i><i>aximus</i>
Journal of Natural Products 2003.0
Synthesis of 2,2-Diphenylpropionate Derivatives and Their Effects on Larval Growth of the Silkworm
Bioscience, Biotechnology, and Biochemistry 2000.0