From Taxuspine X to Structurally Simplified Taxanes with Remarkable P-Glycoprotein Inhibitory Activity

From Taxuspine X to Structurally Simplified Taxanes with Remarkable P-Glycoprotein Inhibitory Activity Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer Ligand-based modeling of diverse aryalkylamines yields new potent P-glycoprotein inhibitors Xanthone analogues as potent modulators of intestinal P-glycoprotein Effects of taxoids from Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cells The synthesis of novel taxoids for oral administration Jatrophane Diterpenes as P-Glycoprotein Inhibitors. First Insights of Structure−Activity Relationships and Discovery of a New, Powerful Lead Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei Sipholane Triterpenoids: Chemistry, Reversal of ABCB1/P-Glycoprotein-Mediated Multidrug Resistance, and Pharmacophore Modeling Structure–Activity Relationships, Ligand Efficiency, and Lipophilic Efficiency Profiles of Benzophenone-Type Inhibitors of the Multidrug Transporter P-Glycoprotein