Semisynthesis of triptolide analogues: Effect of γ-lactone and C-14 substituents on cytotoxic activities

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

Triptolide γ-lactone and C-14 analogues were prepared and evaluated cytotoxity against human lung adenocarcinoma epithelial A549 cells and human colon adenocarcinoma HT-29 cells. γ-Lactone substructure and C-14 substituents affected the biological activities significantly.

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