Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs Largazole and Analogues with Modified Metal-Binding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation Biological Evaluation of New Largazole Analogues: Alteration of Macrocyclic Scaffold with Click Chemistry Synthesis and Biological Characterization of the Histone Deacetylase Inhibitor Largazole and C7- Modified Analogues Synthesis and biological evaluation of largazole zinc-binding group analogs Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue