2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin.

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