Design driven HtL: The discovery and synthesis of new high efficacy β 2 -agonists

Design driven HtL: The discovery and synthesis of new high efficacy β 2 -agonists A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilators Design, synthesis and biological evaluation of 5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one derivatives as potent β2-adrenoceptor agonists Synthesis and Structure−Activity Relationships of Long-acting β₂Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting the β2 adrenoceptor Discovery of highly potent and selective biphenylacylsulfonamide-based β3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the β2-adrenergic receptor: Part 6 Synthesis and Structure−Activity Relationships of Long-acting β₂Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach Discovery of a Highly Selective β₂-Adrenoceptor Agonist with a 2-Amino-2-phenylethanol Scaffold as an Oral Antiasthmatic Agent Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2-(tert-butylamino)ethanol, a compound designed to act as a β2 adrenoceptor agonist Synthesis and biological evaluation of β2-adrenoceptor agonists bearing the 2-amino-2-phenylethanol scaffold