Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport

Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility The synthesis of novel taxoids for oral administration Characterization of Two Taxol Photoaffinity Analogs Bearing Azide and Benzophenone-Related Photoreactive Substituents in the A-Ring Side Chain Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids:  Exceptional Activity against Drug-Resistant Cancer Cells Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein Syntheses and Structure−Activity Relationships of Taxoids Derived from 14β-Hydroxy-10-deacetylbaccatin III