Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

We evaluated antimalarial and/or chloroquine-resistance reversing effects of five opioid receptor antagonists. Although none of the evaluated compounds showed antimalarial effects, some of them, especially the δ(1) receptor antagonist, 7-benzylidenenaltrexone (BNTX) exhibited potent chloroquine-resistance reversing effects in Plasmodium chabaudi.

Knowledge Graph

Similar Paper

Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi
Bioorganic & Medicinal Chemistry Letters 2011.0
Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound
Bioorganic & Medicinal Chemistry Letters 2015.0
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives
Bioorganic & Medicinal Chemistry 2017.0
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones
Bioorganic & Medicinal Chemistry Letters 2011.0
Chlorpheniramine Analogues Reverse Chloroquine Resistance inPlasmodium falciparumby Inhibiting PfCRT
ACS Medicinal Chemistry Letters 2014.0
A Chloroquine-like Molecule Designed to Reverse Resistance in Plasmodium falciparum
Journal of Medicinal Chemistry 2006.0
A New Class of Potential Chloroquine-Resistance Reversal Agents for Plasmodia:  Syntheses and Biological Evaluation of 1-(3‘-Diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines
Journal of Medicinal Chemistry 2000.0
Reversal Agent and Linker Variants of Reversed Chloroquines: Activities against Plasmodium falciparum
Journal of Medicinal Chemistry 2010.0
Pentacycloundecylamines and conjugates thereof as chemosensitizers and reversed chloroquine agents
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis and structure–activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents
European Journal of Medicinal Chemistry 2008.0