Viridaphin A1 Glucoside, a Green Pigment Possessing Cytotoxic and Antibacterial Activity from the Aphid Megoura crassicauda

Journal of Natural Products
2011.0

Abstract

A green pigment, viridaphin A₁ glucoside (1), was isolated from the green aphid Megoura crassicauda. One- and two-dimensional NMR spectrometric analyses of 1 and its aglycone established the structure as an octacyclic compound. Viridaphin A₁ glucoside exhibited cytotoxicity against HL-60 human tumor cells with an IC₅₀ of 23 μM and antibacterial activity against Bacillus subtilis NBRC 3134 with a minimum inhibitory concentration of 10.0 μg/mL. These results suggested that aphid pigments may protect aphids from invasive species, including viruses and bacteria.

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