Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans

Bioorganic & Medicinal Chemistry
2011.0

Abstract

The antifungal spirocyclic guanidine alkaloid, ptilomycalin A, from marine sponge Monanchora arbuscula, inhibits melanogenesis of Cryptococcus neoformans in vitro through inhibition of biosynthesis of laccase in the melanin biosynthetic pathway with an IC(50) of 7.3 μM.

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