Isoxazoles incorporated N-substituted decahydroquinolines: A precursor to the next generation antimicrobial drug

European Journal of Medicinal Chemistry
2012.0

Abstract

We report here a simple entry into N-substituted decahydroisoxazoloquinoline system with substituents at position 3 and 4 from the readily available substrates for the first time. The synthesized isoxazoloquinolines were evaluated against six bacterial and four fungal strains. The results suggest that the decahydroisoxazolo[4,3-c]quinoline scaffold has the potential to be developed into therapeutically useful antimicrobial agents.

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