Development of 4-aminoquinoline-1,3,5-triazine conjugates as potent antibacterial agent through facile synthetic route

Medicinal Chemistry Research
2013.0

Abstract

A series of novel hybrid 4-aminoquinoline-1,3,5 triazine derivatives were developed and subsequently tested against representative Gram-positive and Gram-negative microorganisms for determination of their antibacterial activity. Screening results indicate that, title molecule exhibit moderate to potent activity in comparison to standard. These hybrid derivatives were synthesized through a facile synthetic routes and structure of reaction intermediates as well as target molecules were recognised with the aid of various spectroscopic techniques viz., FTIR, NMR, mass and elemental analysis.

Knowledge Graph

Similar Paper

Development of 4-aminoquinoline-1,3,5-triazine conjugates as potent antibacterial agent through facile synthetic route
Medicinal Chemistry Research 2013.0
Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety
European Journal of Medicinal Chemistry 2010.0
Design, synthesis, and in vitro antimicrobial activities of novel azetidinyl-3-quinazolin-4-one hybrids
Medicinal Chemistry Research 2012.0
Synthesis and antibacterial activity evaluation of metronidazole–triazole conjugates
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1,2,4-triazole moiety
European Journal of Medicinal Chemistry 2009.0
Structure-guided discovery of 1,3,5-triazine–pyrazole conjugates as antibacterial and antibiofilm agent against pathogens causing human diseases with favorable metabolic fate
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis and antimicrobial evaluation of 4,5-diaryl-2-[4-(t-amino)-2-butynyl]-2,4-dihydro-3H-1,2,4-triazol-3-ones
Medicinal Chemistry Research 2012.0
Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria
European Journal of Medicinal Chemistry 2013.0
Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives
Medicinal Chemistry Research 2013.0
New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties
European Journal of Medicinal Chemistry 2010.0