Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain

Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone:  A Potent, Orally Bioavailable Human CB₁/CB₂Dual Agonist with Antihyperalgesic Properties and Restricted Central Nervous System Penetration N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration Pyrazole antagonists of the CB1 receptor with reduced brain penetration Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists Discovery of Agonists of Cannabinoid Receptor 1 with Restricted Central Nervous System Penetration Aimed for Treatment of Gastroesophageal Reflux Disease Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists Discovery and optimization of novel purines as potent and selective CB2 agonists