New triazole derivatives as antifungal agents: Synthesis via click reaction, in vitro evaluation and molecular docking studies

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (5a-5y) which are analogues of fluconazole, have been designed and synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition on the basis of computational docking experiments to the active site of the cytochrome P450 14α-demethylase (CYP51). The in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compound 5l showed the best antifungal activities.

Knowledge Graph

Similar Paper

New triazole derivatives as antifungal agents: Synthesis via click reaction, in vitro evaluation and molecular docking studies
Bioorganic & Medicinal Chemistry Letters 2012.0
Synthesis and antifungal activity of the novel triazole compounds
MedChemComm 2013.0
Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase
European Journal of Medicinal Chemistry 2010.0
Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase
European Journal of Medicinal Chemistry 2009.0
Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase (CYP51)
European Journal of Medicinal Chemistry 2007.0
Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents
Bioorganic & Medicinal Chemistry Letters 2011.0
Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one
European Journal of Medicinal Chemistry 2011.0
Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives
European Journal of Medicinal Chemistry 2011.0
New azoles with antifungal activity: Design, synthesis, and molecular docking
Bioorganic & Medicinal Chemistry Letters 2011.0