Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity

Medicinal Chemistry Research
2014.0

Abstract

2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy) phenyl)naphtho[1,2-d]oxazoles were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.

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